Ultrasound -- Medical Ultrasonography
Ultrasonography is widely utilized in medicine, primarily in gastroenterology, cardiology, gynaecology and obstetrics, urology and endocrinology. It is possible to perform diagnosis or therapeutic procedures with the guidance of ultrasonography (for instance biopsies or drainage of fluid collections).
Strengths and weaknesses
Strengths of ultrasound imaging:
- It images muscle and soft tissue very well and is particularly useful for delineating the interfaces between solid and fluid-filled spaces.
- It renders "live" images, where the operator can dynamically select the most useful section for diagnosing and documenting changes, often enabling rapid diagnoses.
- It shows the structure as well as some aspects of the function of organs.
- It has no known long-term side effects and rarely causes any discomfort to the patient.
- Equipment is widely available and comparatively flexible; examinations can be performed at the bedside.
Weaknesses of ultrasound imaging:
- Ultrasound cannot penetrate bone and performs poorly when there is air between the scanner and the organ of interest. For example, overlying gas in the gastrointestinal tract often makes ultrasound scanning of the pancreas difficult.
- Even in the absence of bone or air, the depth penetration of ultrasound is limited, making it difficult to image structures that are far removed from the body surface, especially in obese patients.
- The method is operator-dependent. A high level of skill and experience is needed to acquire good-quality images and make accurate diagnoses.
Ultrasonography can be enhanced with Doppler measurements, which employ the Doppler effect to assess whether structures (e.g. blood) are moving towards or away from the probe. By calculating the frequency shift of a particular organ, e.g. the jet of blood flow over a heart valve, its velocity and direction can be determined and visualised. This is particularily useful in echocardiography (ultrasonography of the heart) and essential in determining reverse blood flow in the liver vasculature in portal hypertension.
Medical ultrasonography was invented in 1953 at Lund University by cardiologist Inge Edler and Carl Hellmuth Hertz, the son of Gustav Ludwig Hertz, who was a graduate student at the department for nuclear physics.
Edler had asked Hertz if it was possible to use radar to look into the body, but Hertz said this was impossible. However, he said, it might be possible to use ultrasonography. Hertz was familiar with using ultrasonic reflectoscopes for nondestructive materials testing, and together they developed the idea of using this method in medicine.
The first successful measurement of heart activity was made on October 29, 1953 using a device lent from the ship construction company Kockums in Malmö. On December 16 the same year, the method was used to generate an echo-encephalogram (ultrasonic probe of the brain). Edler and Hertz published their findings in 1954.
Parallel developments in Glasgow, Scotland (coincidentally also a major shipbuilding centre) by Professor Ian Donald and colleagues at the Glasgow Royal Maternity Hospital (GRMH) led to the first diagnostic applications of the technique. Donald was an obstetrician with a self-confessed "childish interest in machines, electronic and otherwise", who, having treated the wife of one of the company's directors, was invited to visit the Research Department of marine boilermakers Babcock & Wilcox at Renfrew, where he used their industrial ultrasound equipment to conduct experiments on various morbid anatomical specimens and assess their ultrasonic characteristics. Together with the medical physicist Tom Brown and fellow obstetrican Dr John MacVicar, Donald refined the equipment to enable differentiation of pathology in live volunteer patients. These findings were reported in The Lancet on 7th June 1958 as "Investigation of Abdominal Masses by Pulsed Ultrasound" - possibly one of the most important papers ever published in the field of diagnostic medical imaging.
At GRMH, Professor Donald and Dr James Willocks then refined their techniques to obstetric applications including fetal head measurement to assess the size and growth of the foetus. With the opening of the new Queen Mother's Hospital on Yorkhill in 1964, it became possible to improve these methods even further. Dr Stuart Campbell's pioneering work on fetal cephalometry led to it acquiring long-term status as the definitive method of study of fetal growth. As the technical quality of the scans was further developed, it soon became possible to study pregnancy from start to finish and diagnose its many complications such as multiple pregnancy, fetal abnormality and placenta praevia. Diagnostic ultrasound has since been imported into practically every other area of medicine.
See feature articles:
- Donald I, MacVicar J, Brown TG. Investigation of abdominal masses by pulsed ultrasound. Lancet 1958;1(7032):1188-95. Medline abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=13550965) (PMID 13550965)
- Edler I, Hertz CH. The use of ultrasonic reflectoscope for the continuous recording of movements of heart walls. Kungl Fzsiogr Sallsk i Lund Forhandl. 1954;24:5. Reproduced in Clin Physiol Funct Imaging 2004;24:118-36. Medline abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15165281) (PMID 15165281).