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Drugs at the Clinical Stage

ABX-EGF (panitumumab) AbgenixABGXtargets the epidermal growth factor receptor (EGFr), which is over-expressed in a variety of cancers including lung cancer, breast cancer, bladder, pancreatic, colorectal cancer, kidney and head and neck cancer.
ABX-MA1AbgenixABGXABX-MA1 targets a protein called MUC18, a cell-surface adhesion molecule that is highly expressed on metastatic melanoma cells but not on normal skin cells
ACP-103AcadiaACAD Parkinson's Disease, adjunctive therapy for schizophrenia (Hallucinations, Psychoses)
Onconase (ranpirnase) AlfaCellACELRibonuclease anti-cancer drug,
Entereg (alvimopan)Adolor ADLR pain management of POI and OBD
lidocaine patchAdolor ADLRpostoperative incisional pain
cetrorelixÆterna Zentaris IncAEZSoncology and endocrine therapy
perifosineÆterna Zentaris IncAEZSsignal transduction inhibitor (cancer)
Teverelix,, D63153Æterna Zentaris IncAEZSprostate cancer -BPH
LobaplatinÆterna Zentaris IncAEZSSmall cell lung cancer, breast, chronic myelogenous leukemia (CML)
NeovastatÆterna Zentaris IncAEZSNon-small cell lung cancer
RC-3095Æterna Zentaris IncAEZSMultiple cancers
AG-858Antigenics Inc.AGENChronic myelogenous leukemia (CML)
OncophageAntigenics Inc.AGENMetastatic melanoma, Kidney cancer (renal cell carcinoma)
AG-702Antigenics Inc.AGENGenital herpes
V -Protectants® (AGI-1067) AtherogenicsAGIXchronic inflammatory diseases, such as atherosclerosis, rheumatoid arthritis and asthma
VivitrexAlkermesALKSAlchol Dependence
AIR Insulin AlkermesALKSDiabetes
AIR Epinephrine AlkermesALKSAnaphylaxis
PexelizumabAlexionALXNCardiopulmonary Bypass, Acute Myocardial Infarction
EculizumabAlexionALXNNephritis, Dermatomyositis , Paroxysmal Nocturnal Hemoglinuria
Efaproxiral Allos TherapeuticsALTHBrain metastases from breast cancer, non-small cell lung cancer, cervical cancer
PDX (pralatrexate) Allos TherapeuticsALTHnon-small cell lung cancer, Mesothelioma, non-Hodgkin's Lymphoma
SYMLIN® (pramlintide acetate)AmylinAMLNsynthetic version of human amylin -glucose control with type 1 diabetes
exenatide (synthetic exendin-4)AmylinAMLN type 2 diabetes
Isatoribine (ANA245) AnadysANDSHepatitis C
ANA 380 AnadysANDSHepatitis B
Oral Prodrug ANA971 AnadysANDSreduce the risk of HCV relapse
AMD3100AnorMEDAOM.TOstem cell mobilizer
AMD070AnorMEDAOM.TOchemokine inhibitor for HIV
Insegia(G17DT immunogen)Aphton CorpAPHTcancer and gastrointestinal disease
AP23573AriadARIA solid tumor and blood malignancies
TP10 AvantAVANCardiac Surgery
CETi-I AvantAVANCholesterol Management
CholeraGarde AvantAVANCholera
Ty800AvantAVANTyphoid Fever
Injectable Anthrax AvantAVANAnthrax
Resten-NG Avi BiopharmaAVIIcardiovascular restenosis
AvicineAvi BiopharmaAVIIvaccine -- anti-hCG immune response targeting hCG-producing cancer cells
NeuGene compounds Avi BiopharmaAVIIanti-sense drugs for cancer, polycystic kidney disease, and viral diseases
NeurodexAvanirAVNpseudobulbar affect, neuropathic pain
AV201AviginAVGNsevere Parkinson's disease
PhenserineAxonyxAXYXAlzheimer's disease
Theratope Vaccine BiomiraBIOMcolorectal, metastatic breast cancer
BLP25 Liposome VaccineBiomiraBIOMProstate, non-small cell lung cancer
ModrenalBioenvision BIVNProstate Cancer
Clofarabine (CLOLAR)Bioenvision BIVNpediatric acute lymphoblastic leukemia, solid Tumors
VelostanBioenvision BIVNpost-menopausal advanced breast cancer, bladder cancer
virostatBioenvision BIVNhepatitis C
GVAX (vaccine) Cell GenesysCEGEProstate, lung, pancreatic, leukemia, myeloma
CG7870 Oncolytic Virus TherapyCell GenesysCEGEProstate cancer
Daptomycin (cubicin)CubistCBSTsoft tissue infection, infective endocarditis
HepeX-BCubistCBSTprevention of infection by hepatitis B in liver transplant
Oracea Collagenex Pharmaceuticals Inc CGPIrosacea
E2F DecoyCorgentechCGTKCoronary Bypass Graft, Arterio-Venous Graft
mifepristone ( Corlux)CorceptCORTPsychotic major depression, Alzheimers
XYOTAXCell TherapeuticsCTICnon-small cell lung cancer (NSCLC) and ovarian cancer
PixantroneCell TherapeuticsCTICnon-Hodgkin's lymphoma (NHL
TRISENOXCell TherapeuticsCTICrelapsed/refractory acute promyelocytic leukemia
CT-2106Cell TherapeuticsCTICanti-cancer drug
VentavisCoTherix IncCTRXpulmonary arterial hypertension
RanexaCV Therapeutics IncCVTXChronic Angina
RegadenosonCV Therapeutics IncCVTXMyocardial Perfusion Imaging
TecadenosonCV Therapeutics IncCVTX(PSVT Atrial Fibrillation)
AdentriCV Therapeutics IncCVTXcongestive heart failure (CHF)
MilnacipranCypress BiosciencesCYPBfibromyalgia syndrome (FMS) and related chronic pain conditions
SB-715992CytokineticsCYTK multiple forms of cancer, including combination therapy
provengeDendreon DNDN prostate cancer vaccine
APC8024(Neuvenge)Dendreon DNDNHER-2/neu positive cancers, including breast, ovarian and colorectal cancers
indiplonDOV PharmaceuticalsDOVPinsomnia
bicifadineDOV PharmaceuticalsDOVPpain
ocinaplonDOV PharmaceuticalsDOVPgeneralized anxiety disorder
DOV 216,303DOV PharmaceuticalsDOVPdepression, anxiety and substance abuse
DOV DiltiazenDOV PharmaceuticalsDOVPAngina and Hypertension
DX-88DyaxDYAXhereditary angioedema (HAE)
DX-890DyaxDYAXcystic fibrosis (CF),chronic obstructive airways diseases
Thelin (sitaxsentan)Encysive PharmaceuticalsENCYpulmonary arterial hypertension (PAH)
BIMOSIAMOSEEncysive PharmaceuticalsENCYinhaled therapy for asthma, psoriasis and atopic dermatitis
TBC3711Encysive PharmaceuticalsENCYendothelin A antagonis
Panzem (2-methoxyestradiol) EntreMedENMDcancer
XL119ExelixisEXELbile duct tumors
Macugen(pegaptanib sodium injection)Eyetech PharmaceuticalsEYETwet form of age-related macular degeneration (AMD)
FM-VP4Forbes Medi-TechFMTI cholesterol-lowering and anti-atherosclerotic
Genasense® (oblimersen sodiumGentaGNTA melanoma, lung and prostate cancers
Ganite® (gallium nitrate injection).GentaGNTAcancer related hypercalcemia
TNFeradeGenVec GNVCTumor necrosis factor alpha gene
TVAX Telomerase Cancer Vaccine (TVAX) Geron GERNprostate cancer
Aquavan InjectionGuilford PharmaceuticalsGLFDmild to moderate sedation for non-invasive procedures
GPI 1485Guilford PharmaceuticalsGLFDImpotence, Prostate Cancer
GPI 5693 Guilford PharmaceuticalsGLFDneuropathic pain
MyVaxGenitope CorpGTOPidotypic vaccine for cancer follicular non-Hodgkin's lymphoma (f-NHL).
ACAPODEMEGTX Inc.GTXI Prevention of prostate cancer in men with high grade PIN
AndarineGTX Inc.GTXICachexia from various types of cancer
OstarineGTX Inc.GTXIandropause
HE2100 NEUMUNEHollis-Eden PharmaceuticalsHEPHprotecting the body's bone marrow from acute radiation syndrom
PHOSPHONOLHollis-Eden PharmaceuticalsHEPHprotect against DNA mutations (mutagenesis)-- from radiation
(HE2000) IMMUNITINHollis-Eden PharmaceuticalsHEPHMalaria and HIV and preclinical benefit in a number of tuberculosis model
LymphoStat-BHuman Genome SciencesHGSIdrugs discovered through genomics-based research
AlbuferonHuman Genome SciencesHGSIhepatitis C, b?? and a broad range of cancers
HGS-ETRI Human Genome SciencesHGSIapoptosis, in cancer cells.
HGS-TR2JHuman Genome SciencesHGSIapoptosis, in cancer cells.
480848Human Genome SciencesHGSIinhibits atherosclerotic plaques
IC485ICOSICOSChronic Obstructive Pulmonary Disease
Tadalafil ICOSICOSBenign Prostatic Hyperplasia
FluINsureID Biomedical CorpIDBEvaccine prevention of influenza (flu)
StreptAvaxID Biomedical CorpIDBEvaccine for prevention of diseases caused by group A streptococcus in children
PPV ID Biomedical CorpIDBEvaccine for the prevention of disease caused by Streptococcus pneumoniae (pneumococcus)
PagocioneIndevus Pharmaceuticals IDEVStuttering
PRO2000Indevus PharmaceuticalsIDEVHIV and STD Prevention
IP 751Indevus PharmaceuticalsIDEVPain and Inflammation
Aminocandin Indevus PharmaceuticalsIDEVSerious Fungal Infections
HuN901-DM1ImmunogenIMGNcancers that express the CanAg antigen
MLN2704ImmunogenIMGN-targets the prostate-specific membrane antigen (PSMA)
Cantuzumab mertansineImmunogenIMGNcancers that express the CanAg antigen
Reverset Incyte CorpINCY HIV
CCR2 AntagonistsIncyte CorpINCYRheumatoid Arthritis, MS, Neuropathic Pain, Atherosclerosis
Sheddase InhibitorsIncyte CorpINCYCancer
ADVEXINIntrogen TherapeuticsINGNCancer ?? Advexin (adenoviral p53) --bladder cancer--gene therapy -PI
INGN 241Introgen TherapeuticsINGNtumor suppressor product candidate
INGN 225Introgen TherapeuticsINGNtumor vaccine
Visicol InKline PharamceuticalsINKPConstipation
INKP-102 InKline PharamceuticalsINKPColon cleansing prior to colonoscopy
IB-StatInKline PharamceuticalsINKPSymptoms associated with Irritable Bowel Syndrome (IBS)
CEA-Scan ImmunomedicsIMMU targets tumors that have carcinoembryonic antigen (CEA) on their cell membrane
antisense drugsISIS PharmaceuticalsISIS ulcerative colitis, diabetes, MS, cardiovascular disease, cancer, psoriasis
diquafosol tetrasodium (INS365 Ophthalmic) Inspire PharamceuticalsISPHfor the treatment of dry eye disease
INS37217-- Respiratory (denufosol tetrasodium) Inspire PharamceuticalsISPHcystic fibrosis, retinal disease
IN50589Inspire PharamceuticalsISPHAntiplatelet for Platelet Inhibition
Sulodexide (KRX-101)Keryx BiopharmaceuticalsKERXdiabetic nephropathy
Perifosine (KRX-0401)Keryx BiopharmaceuticalsKERXmultiple forms of cancer
KS 01-019Kos PharmaceuticalsKOSPdyslipidemia
KS 01-018Kos PharmaceuticalsKOSPPeriperhal Arterial Disease
AzmacortKos PharmaceuticalsKOSPtreatment of asthma as prophylactic therapy
TargretinLigand PharmaceuticalsLGNDnon-small cell lung cancer
ONTAK Ligand PharmaceuticalsLGNDB- and T-cell non-Hodgkin's lymphomas and chronic lymphocytic leukemia,
Targretin gelLigand PharmaceuticalsLGNDhand dermatitis
LJP 394La Jolla PharmaceuticalsLJPCLupus Erythematosus, Systemic Lupus Nephritis
Riquent® (abetimus sodiumLa Jolla PharmaceuticalsLJPCsystemic lupus erythematosus (SLE)
CepleneMaxim PharmaceuticalsMAXMAdvanced Melanoma, Acute Myeloid Leukemia, Renal Cell Carcinoma, Hepatitis C
Medarex AntibodiesMedarexMEDX cancer, inflammation, autoimmune and infectious diseases
AnidulafunginVicuron PharmaceuticalsMICUanti-fungal
Dalbavancin Vicuron PharmaceuticalsMICUglycopeptide class of antibiotics (hospital infections)
OxazolidinonesVicuron PharmaceuticalsMICUmost-difficult-to-treat, multi-drug-resistant bacteria
Deformylase Inhibitors Vicuron PharmaceuticalsMICUantibiotic -- respiratory tract infections
INTEGRILIN® (EPTIFIBATIDE)Millenium PharmaceuticalsMLNMcardiovascular
VELCADE® (bortezomib)-Millenium PharmaceuticalsMLNMlung, breast, prostate cancers
MLN1202,MLN2704Millenium PharmaceuticalsMLNMRheumatoid arthritis, multiple sclerosis, inflammation
Technosphere Insulin System MannKind CorpMNKDpulmonary delivery system for diabetes
EnoximoneMyogenMYOGAdvanced Chronic Heart Failure
AmbristentanMyogenMYOGPulmonary Arterial Hypertension
DarusentanMyogenMYOGUncontrolled Hypertension
FlurizanMyriad Genetics IncMYGNAlzheimer's, cancer
StaphVAXNabi BiopharmaceuticalsNABIVaccine for staphylococcus infections
NicVaxNabi BiopharmaceuticalsNABIVaccine for smoking cessation vaccine
Civacir Nabi BiopharmaceuticalsNABIHepatitis C antibody-based therapies
IL13-PE38QQRNeoPharm IncNEOLGlioblastoma Multiforme brain tumor
Liposomal SN38NeoPharm IncNEOLAdvanced cancers; including colorectal and lung
Liposomal c-raf Antisense OligonucleotideNeoPharm IncNEOLAdvanced cancers; including pancreatic (monotherapy and combination with radiation/chemotherapy)
Liposomal Paclitaxel-Easy-to-useNeoPharm IncNEOLAdvanced cancers; including breast cancer, lung and ovarian
IndiplonNeurocrine BiosciencesNBIX insomnia via inhibitory neurotransmitter --- GABA
CRF Receptor AntagonisNeurocrine BiosciencesNBIXAnxiety and depression
NBL- 5788Neurocrine BiosciencesNBIXMultiple Sclerosis
Urocortin 2Neurocrine BiosciencesNBIXAcute congestive heart failure (CHF)
GnRH antagonists Neurocrine BiosciencesNBIXEndometriosis
PREOS® (recombinant human parathyroid hormone)NPS PharmaceuticalsNPSP treatment of osteoporosis
TeduglutideNPS PharmaceuticalsNPSP gastrointestinal disorders including Short Bowel Syndrome
PreotactNPS PharmaceuticalsNPSP Osteoperosis
CalcilyticsNPS PharmaceuticalsNPSP Osteoperosis
GlyT-1NPS PharmaceuticalsNPSP Schizophrenia
FibrillexNeurochem Inc.NRMXAA Amyloidosis
AlzhemedNeurochem Inc.NRMXAlzheimer's Disease --inhibit the Amyloid Cascade
CerebrilNeurochem Inc.NRMXHemorrhagic stroke due to cerebral amyloid angiopathy
Memantine (Namenda)Neurobiological Tech NTIIprogressive neurological impairment due to neuronal injur
XERECEPT -- natural human peptide CRFNeurobiological TechNTII inhibitor of swelling, or edema
VIPRINEX™ (ancrod)Neurobiological TechNTIIstroke patients -- anticoagulation
BiDilNitroMed NTMDHeart failure, or end-stage cardiovascular disease
AlfimepraseNuveloNUVOthrombolytic agent or blood clot dissolver
rNAPc2NuveloNUVOFactor VIIa / Tissue Factor Inhibitor
ARC183 Nuvelo NUVODNA-based direct thrombin inhibitor-- anticoagulant / anti-thrombotic
BAY 43-9006Onyx PharmaceuticalsONXXadvanced renal (kidney) cancer
RamoplaninOscient PharmaceuticalsOSCIClostridium difficile-associated diarrhea
FACTIVEOscient PharmaceuticalsOSCIIntravenous-- Bacterial Infections
CA4P (combretastatin)-- OxigeneOXGN Vascular targeting agent ??CK PHASE
Motexafin gadoliniumPharmacyclics Inc. PCYCanti-cancer product
Motexafin lutetiumPharmacyclics IncPCYCreduce or eliminate “vulnerable plaque ”
ApanPraecis PharmaceuticalsPRCSAlzheimer's Disease
PPI-2458Praecis PharmaceuticalsPRCSNon-Hodgkin's Lymphoma/RA
MNTXProgenics Pharmaceuticals PGNXAdvanced medical ilness, post-operative ileus, chronic pain
GMX Progenics PharmaceuticalsPGNXMelanoma Cancer
PSMAProgenics PharmaceuticalsPGNXprostate cancer
PRO542Progenics PharmaceuticalsPGNXHIV
PRO 140Progenics PharmaceuticalsPGNXHIV
TreximaPOZEN Inc.POZN migraine pain
OXYTREXPain Therapeutics Inc.PTIEsevere chronic pain, such as low back, osteoarthritic pain or cancer pain
REMOXYPain Therapeutics Inc.PTIEproprietary abuse-resistant version of time-release oxycodone
PTI-901Pain Therapeutics Inc.PTIEchronic Irritable Bowel Syndrome (IBS).

Regeneron Pharmaceuticals

REGNpotential treatment of obesity
VEGF TrapRegeneron PharmaceuticalsREGNinihibits tumor blood vessel growth
L-4/13 TrapRegeneron PharmaceuticalsREGNtreatment in allergy and asthma
IL-1 Trap Regeneron PharmaceuticalsREGNdecreases inflammation and blocks cartilage erosion in the joint -- Rhematoid Arthritis
ZADAXINSciclone PharmaceuticalsSCLNviral infections-- hepatitis C, and cancer
SCV-07Sciclone PharmaceuticalsSCLNfight infection
SGN-30Seattle Genetics SGENHodgkin's disease and some types of non-Hodgkin's lymphoma
SGN-15Seattle Genetics SGENnon-small cell lung cancer
SGN-40Seattle Genetics SGENmultiple myeloma and non-Hodgkin's lymphoma
XIFAXAN™ (rifaximin)Salix Pharmaceuticals SLXPgastrointestinal- selective, oral antibiotic
ZEGERIDSantarus Inc SNTSHeartburn/GERD, Erosive esophagitis, Duodenal ulcers
OrathecinSupergen Inc.SUPGpancreatic cancer
Avicine™Supergen Inc.SUPGcolorectal cancer
SatraplatinSpectrum PharmaceuticalsSPPI Prostate Cancer
SPI-153Spectrum PharmaceuticalsSPPIHormone Depenmdent Prostate Cancer
EOquin Spectrum PharmaceuticalsSPPI Bladder Cancer, Radiation Sensitizer
ElsamitrucinSpectrum PharmaceuticalsSPPI

Non-Hodgkin's Lymphoma

prosaptideSavientSVNTperipheral neuropathic pain
puricaseSavientSVNTsymptomatic gout
fibrimageSavientSVNTdiagnostic agent for the detection of deep vein thrombosis
I2S Transkaryotic TherapiesTKTXHunter syndrome
GA-GCB Transkaryotic TherapiesTKTXGaucher disease
TELCYTA (TLK286)Telik Inc.TELKadvanced ovarian cancer and non-small cell lung cancer (a selective apoptotic agent)
TELINTRATelik Inc.TELKmyelodysplastic syndrome --Bone marrow stimulant
TNX -355Tanox Inc. TNOXHIV
T-1249Trimeris Inc. TRMSHIV
PivanexTitan PharmaceuticalsTTPRefractory Chronic Lymphocytic Leukemia
DITPATitan Pharmaceuticals Congestive Heart Failure
ProbuphineTitan Pharmaceuticals Opiate addition
SpheramineTitan Pharmaceuticals Advanced Parkinson's
IloperidoneTitan Pharmaceuticals Schizophrenia
Gallium Maltolate Titan Pharmaceuticals Bone Disease
OvaRexUnited Therapeutics CorpUTHR Ovarian Cancer
RemodulinUnited Therapeutics CorpUTHRCritical limb ischemia (CLI)
UT-231BUnited Therapeutics CorpUTHRHepatitis C
CelacadeVasogen Inc.VSGNChronic Heart Failure, Periperheral Arterial Disease
VP025Vasogen Inc.VSGNAlzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis
VX-385Vertex PharmaceuticalsVRTXHIV infection
Merimepodib Vertex PharmaceuticalsVRTXhepatitis C
VX-950Vertex PharmaceuticalsVRTXhepatitis C
VX-765Vertex PharmaceuticalsVRTXcytokine inhibitor of interleukin-1 beta converting enzyme (ICE)
VX-702 Vertex PharmaceuticalsVRTXacute coronary syndromes
Pralnacasan Vertex PharmaceuticalsVRTX inflammatory diseases
VX944, VX630Vertex PharmaceuticalsVRTXCancer
DNA Vaccines Vical Inc VICLmalaria, cytomegalovirus, eboa, west nile virus, hiv, hepatitis
AvanafilVivus Inc. VVUSerectile dysfunction
ALISTAVivus Inc.VVUSfemale sexual arousal disorder
Testosterone MDTSVivus Inc.VVUSlow sexual desire
EvamistVivus Inc.VVUSsymptoms associated with menopause
NeuprexXOMA LTDXOMAimmunologic and inflammatory disorders, cancer and infectious diseases
MLN2222XOMA LTDXOMAcoronary artery bypass graft (CABG) surgery patients.
TransMIDXenova Group XNVAGlioblastoma multiforme (GBM)
XR303Xenova Group XNVAPancreatic Cancer
XR5944/XR11576Xenova Group XNVASolid Tumors
TA-CD VaccineXenova Group XNVACocaine addition
TA_NIC Vaccine Xenova Group XNVANicotine Addiction
Recombinant human Thrombin Zymogenetics Inc. ZGENcontrol of bleeding associated with various surgical procedures
-TACI-IgZymogenetics Inc.ZGENautoimmune diseases and for advanced B-cell malignancies
Interleukin 21 (IL-21)Zymogenetics Inc.ZGENcancer

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