BIOTECH100
IS A GLOBAL STOCK INDEX CONSISTING OF 100 SMALL CAP BIOTECH COMPANIES THAT HAVE
LEAST ONE DRUG BEING CLINICALLY TESTED IN PHASE II OR III --(CLASS A -- EMPHASIS
ON SMALL MOLECULE DRUGS)
| Company | Symbol |
Area of focus |
| Acadia | ACAD | small-molecule drugs for the treatment of central nervous system disorders --schizophrenia, parkinson's disease |
| Adolor | ADLR | pain management |
| Æterna Zentaris Inc | AEZS | oncology and endocrine therapy, signal transduction inhibitors for cancer treatment |
| AtheroGenics | AGIX | inflammatory diseases, heart disease, rheumatoid arthritis, organ transplant rejection and asthma |
| Alexion | ALXN | hematologic, cardiovascular and autoimmune disorders |
| Allos Therapeutics | ALTH | small molecule drugs for improving cancer treatment |
| Amarin Corp Plc | AMRN | development and commercialization of novel drugs for the treatment of neurological disorders affecting the central nervous system. Miraxion for HD. |
| Amylin | AMLN | diabetes, obesity and cardiovascular disease |
| Anadys | ANDS | chronic viral and bacterial infections --hepatitis B, hepatitis C) |
| AnorMED | AOM.TO | chemokine inhibitor for HIV; stem cell mobilizer |
| Aphton Corp | APHT | cancer and gastrointestinal disease |
| Ariad | ARIA | treat cancer by regulating cell signaling with small molecules |
| Avant | AVAN | cardiovascular disease, bacterial and viral diseases, and biodefense and food safety |
| Avi Biopharma | AVII | cardiovascular disease, infectious disease and cancer |
| Avanir | AVN | pseudobulbar affect and chronic diabetic neuropathic pain |
| Axonyx | AXYX | central nervous system drugs |
| Barrier Therapeutics Inc | BTRX | development and commercialization of pharmaceutical products in the field of dermatology |
| Biocryst Pharmaceuticals | BCRX | small molecule pharmaceuticals that block key enzymes essential for cancer, cardiovascular and autoimmune diseases and viral infections |
| Biomarin | BMRN | biopharmaceuticals for serious diseases and medical conditions |
| Biomira | BIOM | immunotherapeutic or cancer vaccine |
| Bioenvision | BIVN | drugs to treat cancer |
| Cardiome Pharma Corp | CRME | developing drugs to treat or prevent cardiac diseases. |
| Cubist | CBST | antibiotics to inhibit specific bacterial targets |
| Corcept | CORT | severe psychiatric and neurological diseases |
| CuraGen Corp | CRGN | novel protein, antibody and small molecule therapeutics in the areas of oncology, inflammatory diseases, obesity and diabetes, and central nervous system disorders |
| Cell Therapeutics | CTIC | novel treatments for cancer |
| Collagenex Pharmaceuticals | CGPI | dental and dermatology markets |
| CoTherix Inc | CTRX | cardiopulmonary and other chronic diseases |
| CV Therapeutics Inc | CVTX | new small-molecule drugs for the treatment of cardiovascular diseases |
| Cypress Biosciences | CYPB | functional somatic syndromes and other related chronic pain and central nervous system disorders |
| Cytokinetics | CYTK | small-molecule drugs that specifically target the cytoskeleton |
| DOV Pharmaceuticals | DOVP | central nervous system and other disorders, including cardiovascular, --insomnia |
| Ecopia | EIA.TO | development of anticancer, antibacterial and antifungal agents |
| Encysive Pharmaceuticals | ENCY | cardiovascular and inflammatory diseases |
| EntreMed | ENMD | panzem (2-methoxyestradiol) estrogen |
| Exelixis | EXEL | human therapeutics -- uses comparative genomics and model system genetics --small drug molecules |
| Eyetech Pharmaceuticals | EYET | novel therapeutics to treat diseases of the eye |
| Forbes Medi-Tech | FMTI | cardiovascular and related diseases using plant sterols |
| Genta | GNTA | cancer and related diseases |
| Genaera Corp | GENR | genomics and natural products.--anti-angiogenesis and respiratory diseases** small molecule??? |
| Geron | GERN | anti-cancer therapies based on telomerase inhibitors, telomerase therapeutic vaccines |
| Guilford Pharmaceuticals | GLFD | hospital and neurology markets -- alzheimer's, parkinson's disease |
| Genitope Corp | GTOP | idotypic vaccine for cancer (lymphoma) MyVax |
| GTX Inc. | GTXI | molecules that selectively modulate the effects of estrogens and androgens |
| Hollis-Eden Pharmaceuticals | HEPH | treatment for immune system and metabolic disorders |
| Human Genome Sciences | HGSI | drugs discovered through genomics-based research |
| ICOS | ICOS | serious unmet medical needs (COPD) |
| Immtech International Inc | IMM | oral drugs to treat infectious diseases, as well as metabolic (diabetes) and neoplastic (cancer) disorders |
| Indevus Pharmaceuticals | IDEV | development and commercialization of a diversified portfolio of pharmaceutical product --over active bladder |
| Icagen Inc. | ICGN | development and commercialization of novel orally administered small molecule drugs that modulate ion channel targets |
| Incyte Corp | INCY | small molecule drugs to treat HIV, inflammation, cancer and diabetes |
| Idenix Pharmaceuticals Inc | IDIX | development of drugs for the treatment of human viral and other infectious diseases. The Company focuses on the treatment of infections caused by hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) |
| InKline Pharamceuticals | INKP | diagnosis and treatment of gastrointestinal disorders |
| Inspire Pharamceuticals | ISPH | ophthalmic and respiratory therapeutic areas |
| Keryx Biopharmaceuticals | KERX | life-threatening diseases, including diabetes and cancer |
| Kos Pharmaceuticals | KOSP | treatment of chronic cardiovascular and respiratory diseases |
| Kosan Biosciences | KOSN | developing drug candidates from a class of natural product compounds known as polyketides |
| Ligand Pharmaceuticals | LGND | areas of cancer, pain, hormone-related health issues, skin diseases, osteoporosis and metabolic, cardiovascular and inflammatory diseases |
| La Jolla Pharmaceuticals | LJPC | antibody-mediated diseases. These diseases, including autoimmune conditions, such as lupus and antibody-mediated thrombosis - |
| Maxim Pharmaceuticals | MAXM | therapeutic candidates for life-threatening cancers and liver diseases |
| Metabasis Therapeutics Inc | MBRX | small-molecule drugs to treat liver diseases and metabolic diseases linked to pathways in the liver. |
| MGI Pharma Inc. | MOGN | products that meet cancer patient needs |
| Vicuron Pharmaceuticals | MICU | anti-fungal and anti-bacterial drugs |
| Momenta Pharmaceuticals | MNTA | design of complex sugars (polysaccharides) for the development of improved versions of existing drugs |
| Myogen | MYOG | small molecule therapeutics for the treatment of cardiovascular disorders |
| Myriad Genetics Inc | MYGN | Alzheimer's, cancer, infectious diseases |
| Nabi Biopharmaceuticals | NABI | infectious, autoimmune and addictive diseases |
| Neurocrine Biosciences | NBIX | neurological and endocrine-related diseases and disorders-- insommia |
| NPS Pharmaceuticals | NPSP | bone and mineral disorders, gastrointestinal disorders and central nervous system disorders |
| Neurochem Inc. | NRMX | inhibit both the formation of amyloid fibrils and the resulting toxic deposits in Alzheimer's |
| Neurobiological Tech | NTII | neuroprotective and neuromodulatory agents --diabetic neuropathy and brain cancer |
| NitroMed | NTMD | therapeutic benefits of the naturally occurring molecule nitric oxide |
| Onyx Pharmaceuticals | ONXX | therapies that target the molecular mechanisms that cause cancer |
| Oscient Pharmaceuticals | OSCI | unmet medical needs |
| Oxigene 75 | OXGN | CA4P (combretastatin)-- new second-generation vascular targeting agents |
| Prana Biotechnology Ltd | PRAN | therapeutic drugs designed to treat the underlying causes of brain and eye degeneration as a result of the aging process |
| Pharmacyclics Inc. | PCYC | cancer and atherosclerosis |
| Praecis Pharmaceuticals | PRCS | Alzheimer’s Disease, cancer |
| Progenics Pharmaceuticals | PGNX | patients with debilitating conditions and life-threatening diseases |
| Pharmion | PHRM | products for the treatment of hematology and oncology patients |
| POZEN Inc. | POZN | pipeline in the field of migraine |
| Pain Therapeutics Inc. | PTIE | pain associated with advanced osteoarthritis, low-back pain or irritable bowel syndrome, cancer |
| Regeneron | REGN | cancer, diseases of the eye, rheumatoid arthritis and other inflammatory conditions, allergies, asthma, obesity |
| Rigel | RIGL | small molecule product candidates for unmet medical needs |
| Renovis Inc | RNVS | major medical needs in the areas of pain, trauma and stroke and neurodegenerative diseases. |
| Salix Pharmaceuticals | SLXP | gastrointestinal diseases that affect the digestive tract |
| Santarus Inc | SNTS | prevention and treatment of gastrointestinal diseases and disorders |
| Supergen Inc. | SUPG | solid tumors, hematological malignancies and blood disorders |
| Savient | SVNT | pharmaceutical products; oral liquid products; HgH |
| Spectrum Pharmaceuticals | SPPI | Oncology Strategy and the Generic Drug Strategy |
| Telik Inc. | TELK | discovers, develops and commercializes small molecule drugs to treat serious diseases |
| Trimeris Inc. | TRMS | new class of antiviral drug treatments called fusion inhibitors |
| Titan Pharmaceuticals | TTP | therapeutics for the treatment of central nervous system (CNS) disorders, cancer and cardiovascular disease |
| United Therapeutics Corp | UTHR | chronic and life-threatening cardiovascular, infectious and oncological diseases. |
| Vion Pharmaceuticals Inc | VION | technologies for the treatment of cancer.--small molecules |
| ViroPharma Inc | VPHM | activities on viral diseases, including cytomegalovirus (CMV) infections related to hematopoietic stem cell (bone marrow) |
| Vasogen Inc. | VSGN | cardiovascular, neurological and other chronic inflammatory diseases |
| Vertex Pharmaceuticals | VRTX | small molecule drugs (HIV) infection, chronic hepatitis C virus (HCV), inflammatory and autoimmune disorders and cancer |
| Vivus Inc. | VVUS | products to restore sexual function in men and women |
| Xenova Group | XNVA | cancer and addiction with a secondary focus on immunology |