| Company | Symbol |
Area of focus |
| Abgenix | ABGX | antibodies for the treatment of a variety of disease conditions, including cancer |
| Acambis PLC | ACAM | developer of vaccines against infectious diseases |
| Alkermes | ALKS | products based on drug delivery technologies |
| AlfaCell | ACEL | Onconase (ranpirnase) --a ribonuclease anti-cancer drug |
| Antigenics Inc. | AGEN | cancers, infectious diseases and autoimmune disorders |
| Alnylam Pharmaceuticals Inc | ALNY | therapeutics based on a biological pathway, RNA interference (RNAi). |
| Albany Molecular Research | AMRI | chemistry-based drug discovery and development company |
| ANGIOTECH Pharmaceuticals | ANPI | drug-eluting medical devices and biomaterials |
| ADVENTRX Pharmaceuticals | ANX | biomedical research and development business focused on treatments for viral infections and cancer--developmental stages |
| A.P. Pharma | APPA | development and commercialization of bioerodible injectable and implantable systems |
| Arena Pharmaceuticals | ARNA | drug targets called G protein-coupled receptors (GPCRs) |
| Aastrom Biosciences | ASTM | adult stem cell-based products for the regenerative repair of damaged human tissue--cell repair |
| Avigen | AVGN | chronic hematological and neurological diseases |
| Cell Genesys | CEGE | cell-based cancer vaccines, oncolytic virus therapies and antiangiogenesis therapies, cancer treatment |
| Cerus | CERS | therapeutics and vaccines to enhance the safety of blood products used for transfusion |
| Cambridge Antibody Technology | CATG | discovery and drug development of human monoclonal antibodies as new treatments for human disease |
| Corgentech | CGTK | transcription factor decoys (TF decoys). |
| CancerVax Corporation | CNVX | development and commercialization of novel biological products for the treatment and control of cancer. |
| Cortex Pharmaceuticals | COR | neurodegenerative diseases and other neurological and psychiatric disorders |
| Curis Inc | CRIS | modulate key regulatory signaling pathways controlling the repair and regeneration of human tissues and organs. |
| Critical Therapeutics Inc | CRTX | therapeutic products designed to regulate the inflammatory response associated with asthma and critical care diseases -- cytokines-- |
| Corixa | CRXA | immunotherapeutic products, including monoclonal antibodies, vaccines and adjuvants and small molecules |
| Crucell NV | CRXL | produce novel vaccines and antibodies |
| Cell Science | CVM | cytokines to stimulate the immune system (low) |
| deCODE genetics | DCGN | drugs and deoxyribonucleic acid (DNA)-based diagnostics --ppeline??? |
| Dendreon | DNDN | therapeutic vaccines, monoclonal antibodies, small molecules and pro-drugs for cancer |
| Depomed | DEPO | drug delivery |
| Digene | DIGE | gene-based testing systems for the screening, monitoring and diagnosis of human diseases |
| Durect Corp | DRRX | drug delivery platform technologies that treat chronic debilitating diseases and enable biotechnology products. |
| Discovery Labs | DSCO | lung surfact technology |
| DUSA Pharmaceuticals | DUSA | Levulan PD --Photodynamic therapy |
| Diversa | DVSA | novel protein-based products, including enzymes, as well as small molecules |
| Dyax | DYAX | antibody, protein and peptide based therapeutic products |
| Enzon | ENZN | PEG modification and single-chain antibody (SCA®) technologies |
| Exact Sciences | EXAS | develops and commercializes proprietary DNA (deoxyribonucleic acid)-based tests for the early detection of cancer |
| Flamel Technologies | FLML | development of polymer-based delivery technologies for medical applications. |
| Favrille Inc. | FVRL | targeted immunotherapies for the treatment of cancer and diseases of the immune system. |
| Gene Logic Inc | GLGC | provides services to organizations involved in the drug discovery and development business. |
| Genetronics | GEB |
uses Electroporation Therapy (EPT) to deliver drugs and genes into cells |
| Genelabs Technologies | GNLB | drug for women with systemic lupus erythematosus, |
| GenVec | GNVC | gene delivery systems --TNFerade--tumor necrosis factor alpha gene |
| GPC Biotech AG | GPCB | developing new drugs to treat cancer satraplatin and monoclonal antibodies |
| Genitope Corp | GTOP | idotypic vaccine for cancer (lymphoma) MyVax |
| Helix Biopharma Corp | HBP.TO | cancer therapeutics |
| ID Biomedical Corp | IDBE | development of subunit vaccines |
| Illumina Inc. | ILMN | analysis of genetic variation and function |
| Immunogen | IMGN | therapeutic monoclonal antibodies and novel treatments in the field of oncology |
| Immune Response | IMNR | immune-based therapies (IBT) for the prevention and treatment of human immunodeficiency virus (HIV) |
| Immunomedics | IMMU | monoclonal antibody-based products for the targeted treatment of cancer, autoimmune diseases |
| Introgen Therapeutics | INGN | targeted therapies for the treatment of cancer and other diseases using gene therapy -- virus therapy |
| Inhibitex Inc | INHX | antibody-based products for the prevention and treatment of bacterial and fungal infections in the hospital setting |
| Insmed Inc | INSM | treatment of metabolic diseases and endocrine disorders associated with insulin resistance |
| Impax Laboratories | IPXL | controlled-release of drugs technologies |
| ISIS Pharmaceuticals | ISIS | ribonucleic acid- (RNA) based drug discovery technologies --antisense drugs |
| Ista Pharmaceuticals Inc | ISTA | diseases and conditions of the eye. |
| Intermune Inc | ITMN | developing and commercializing products for the treatment of serious pulmonary and hepatic diseases |
| LEXG | gene knockout technology to discover the physiological functions of genes in living mammals (in vivo | |
| Lifecell | LIFC | products made from human allograft tissue for use in reconstructive, urogynecologic and orthopedic surgical procedures |
| Maxygen Inc | MAXY | protein optimization and modification technologies to create and develop novel therapeutic and industrial products |
| Medarex | MEDX | antibody-based therapeutics for:cancer, inflammation, autoimmune and infectious diseases |
| MannKind Corp | MNKD | diabetes, cancer, inflammatory and autoimmune diseases-- Technosphere® inhalation system |
| NeoPharm Inc | NEOL | treatment of various cancers --NeoLipid Technology |
| Nanogen, Inc | NGEN | develops and commercializes molecular diagnostics products and tests for the gene-based testing market |
| Northfield Labs | NFLD | alternative to transfused blood for use in the treatment of acute blood loss |
| Nektar Therapeutics | NKTR | technologies to improve drug performance throughout the drug development process.--helping other companies... |
| Noven Pharmaceuticals | NOVN | transdermal drug delivery technologies |
| Nuvelo | NUVO | treatment of acute cardiovascular indications and cancer. |
| Neorx Corp | NERX | oncology products --bone-targeting radiopharmaceutical |
| Nastech Pharmaceuticals | NSTK | drug delivery systems.... has pipeline ??? or drug company??? |
| Novavax | NVAX | delivery and vaccine development. |
| Neose Technologies | NTEC | modify carbohydrate structures on glycoproteins |
| Orchid Biosciences | ORCH | develops and delivers genetic testing, services that generate information related to genetic susceptibility |
| Pharmacyclics | PCYC | Xcytrin (motexafin) Texaphyrins radiosensitizer xxxx ?? drug company |
| Protein Design | PDLI | humanized monoclonal antibodies for the treatment of disease, particularly inflammatory bowel disease and cancer |
| Pharmion Corp 75 | PHRM | hematology and oncology patients |
| Polydex | POLXF | manufacture and marketing of biotechnology-based products for the human pharmaceutical market |
| PAREXEL International Co | PRXL | medical marketing, consulting and informatics and advanced technology products and services |
| Penwest Pharmaceuticals | PPCO | oral drug delivery technologies |
| QLT Inc | QLTI | eye diseases, cancer and dermatological conditions using photodynamic therapy (PDT) |
| Repligen Corp | RGEN | neuropsychiatric disorders and autoimmune diseases |
| Sirna Therapeutics Inc | RNAI | ribonucleic acid (RNA)-based molecules for therapeutic and diagnostic purposesxxxx((( |
| Sciclone Pharmaceuticals | SCLN | hepatitis C virus (HCV), the hepatitis B virus (HBV) and certain types of cancer |
| Serologicals Corp | SERO | manufacture of biologically based life science products. |
| Seattle Genetics | SGEN | monoclonal antibody-based therapeutic products for the treatment of cancer and immunologic diseases. |
| Sangamo Biosciences | SGMO | development and commercialization of novel transcription factors for the regulation of gene expression |
| Sonus | SNUS | TOCOSOL drug delivery technology. The TOCOSOL technology platform, designed to address the formulation challenges of therapeutic drugs, uses vitamin E oil (tocopherol) and tocopherol derivatives to solubilize and stabilize |
| SFBC International Inc | SFCC | drug development services to branded pharmaceutical, |
| Sangamo Biosciences | SGMO | development and commercialization of novel transcription factors for the regulation of gene expression |
| Stem Cells Inc. | STEM | Stem cell technology |
| Techne Corp | TECH | research and diagnostic systems |
| Tanox Inc. | TNOX | monoclonal antibodies-- asthma, allergy, inflammation, and infectious diseases. |
| Targeted Genetics | TGEN | Gene therapy -- for cystic fibrosis --- working with Sirna |
| Transkaryotic Therapies | TKTX | genetic diseases caused by protein deficiencies |
| Trinity Biotech | TRIB | develops, manufactures and markets diagnostic test kits used for the clinical laboratory and point-of-care segments of the diagnostic market. |
| Corautus Genetics Inc | VEGF | gene therapy products for the treatment of cardiac and vascular disease. |
| Viacell | VIAC | application of human cells as medicine. |
| Vical | VICL | vaccines -- infectious diseases and cancer |
| Vical Inc | VICL | biopharmaceutical products based on its deoxyribonucleic acid (DNA) delivery technologies for the prevention and treatment of serious or life-threatening diseases |
| XOMA LTD | XOMA | immunologic and inflammatory disorders, cancer and infectious diseases |
| ZymoGenetics | ZGEN | therapeutic proteins for the treatment of human disease |